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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Methoxy polyethylene glycol-epoetin beta ： ウィキペディア英語版 Methoxy polyethylene glycol-epoetin beta Methoxy polyethylene glycol-epoetin beta is the active ingredient of a drug marketed by Hoffmann-La Roche under the brand name Mircera. Mircera is a long-acting erythropoietin receptor activator (CERA) indicated for the treatment of patients with anaemia associated with chronic kidney disease. It is the first approved, chemically modified erythropoiesis-stimulating agent (ESA). Mircera is supplied as a solution in pre-filled syringes for intravenous or subcutaneous administration. Mircera was approved for use in Europe in July 2007 by the European Commission, in September 2007 by the Swissmedic, and in November 2007 by the U.S. Food and Drug Administration for use in the United States. Methoxy polyethylene glycol-epoetin beta is made from erythropoietin by chemically linking the N-terminal amino group or the Є-amino group of any lysine present in the protein with methoxy polyethylene glycol butanoic acid. The average molecular weight is approximately 60kDa. The drug stimulates erythropoiesis by interacting with the erythropoietin receptor on progenitor cells in the bone marrow.〔It has a different receptor binding activity to other ESAs and its reduced affinity for the erythropoietin receptor allows continuous stimulation. It has an ''in vivo'' half-life of around 135 hours as compared to darbapoietin alfa which has a half life of around 21 hours, the half life of which is three times that of the naturally occurring erthropoietin in the body. ==Patent infringement claims== A U.S. Federal Appeals Court ruled 15 September 2009 that Mircera infringes a patent held by Amgen Inc. The court refused to lift an injunction entered in the fall of 2008 which barred Roche from selling Mircera in the United States.〔(Update: US Court Won't Disturb Injunction Against Roche Anemia Drug ) Brent Kendall, Dow Jones Newswires Tuesday, September 15, 2009.〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Methoxy polyethylene glycol-epoetin beta」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.